Banca de QUALIFICAÇÃO: GUSTAVO FERNANDES DE SOUSA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: GUSTAVO FERNANDES DE SOUSA
DATA: 30/06/2020
HORA: 09:00
LOCAL: Banca Remota via Web conferência
TÍTULO: Click Chemistry-based Chondroitin Sulfate-Arm PEGs Hydrogels for Skin Tissue Engineering
PALAVRAS-CHAVES: Click chemistry, Chondroitin Sulfate, Multi-Arm PEG, Fibroblast, Skin Tissue engineering.
PÁGINAS: 35
GRANDE ÁREA: Engenharias
ÁREA: Engenharia Biomédica
SUBÁREA: Engenharia Médica
ESPECIALIDADE: Biomateriais e Materiais Biocompatíveis
RESUMO:

Chondroitin sulfate (CS) is used to manufacture a clickable reagent for a rapid, solvent-free synthesis of chondroitin sulfate-polyethylene glycol (CS-PEG) hydrogels. Furthermore, different multi-arm PEGs are used to produce cross-linked copolymers with suitable and tunable properties easily prepared by norbornene-tetrazine click methodology. Structural characterizations were performed to confirm the CS modification and the structure of the final material. Gelation time and Young's modulus are measured, varying the arm's number and multi-arm PEG's chain size. Moreover, the cell viability was investigated by adhesion test with murine fibroblast cell line. To demonstrating the capability of this strategy, different hydrogels are fabricated in a few minutes with mechanical and biological controlled properties for future skin tissue engineering applications.

MEMBROS DA BANCA:
Presidente - 1397472 - ANDERSON DE OLIVEIRA LOBO
Interno - 1570906 - BARTOLOMEU CRUZ VIANA NETO
Interno - 1780191 - FRANCISCO ERONI PAZ DOS SANTOS
Externo à Instituição - SAMSON AFEWERKI - HARVARD