Banca de DEFESA: CATERINE YESENIA CARRASCO MONTESDEOCA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: CATERINE YESENIA CARRASCO MONTESDEOCA
DATA: 18/02/2020
HORA: 08:30
LOCAL: Auditorio do PPGCM
TÍTULO: Oxygen-generating Smart hydrogels Supporting Chondrocytes Cell Survival in Hypoxic Environments
PALAVRAS-CHAVES: Matrix of methacryloyl gelatin (GelMA), Calcium peroxide (CPO), Release kinetics, chondrocytes cell
PÁGINAS: 35
GRANDE ÁREA: Engenharias
ÁREA: Engenharia de Materiais e Metalúrgica
SUBÁREA: Materiais Não-Metálicos
ESPECIALIDADE: Polímeros, Aplicações
RESUMO:

Cartilage is one of our body ’s tissues which are not repaired automatically by itself. Problems associated with cartilage are very common worldwide and are considered the leading causes of pain and disability. Smart biomaterial or “Four dimensional” (4D) biomaterials has started emerging as a suitable candidate, which are principally three-dimensional (3D) materials that change their morphology or to generate a response measured at space and time to physiologic stimuli. In this context, the release of oxygen through hydrogels in contact with water is considered as 4D biomaterials. The objective of this study is to develop strategies to release oxygen in a sustainable and prolonged manner through hydrogels systems to promote chondrocytes cell survival in hypoxic environment. The 4D biomaterials are devised from gelatin methacryloyl (GelMA) loaded with calcium peroxide (CPO) and have the ability to generate oxygen in a c ontrolled and sustained manner for up 6 days. The incorporation of CPO into the hydrogel system provided materials with enhanced mechanical and porosity properties. Furthermore, the hydrogels promoted chondrocyte survival and reduced cell death under hypoxic conditions.

MEMBROS DA BANCA:
Presidente - 1397472 - ANDERSON DE OLIVEIRA LOBO
Interno - 1570906 - BARTOLOMEU CRUZ VIANA NETO
Externo à Instituição - ANTONIO LUIZ MARTINS MAIA FILHO - UESPI