Banca de QUALIFICAÇÃO: AURILEIDE MARIA BISPO FRAZÃO SOARES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE: AURILEIDE MARIA BISPO FRAZÃO SOARES
DATA: 23/03/2021
HORA: 08:30
LOCAL: sala virtual - https://meet.google.com/kfe-ryvc-jwu
TÍTULO: Imobilização da enzima papaina em suporte híbrido contendo nanopartículas de óxido de zinco e quitosana para aplicações clínicas
PALAVRAS-CHAVES: zinc oxide nanoparticles, chitosan, papain, biomedical applications
PÁGINAS: 10
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Inorgânica
ESPECIALIDADE: Físico Química Inorgânica
RESUMO:

A new hybrid bionanomaterial composed of zinc oxide nanoparticles (ZnO NPs) and chitosan was constructed after enzymatic immobilization of papain for biomedical applications. In this work, we report the preparation and characterization steps of this bionanomaterial and its biocompatibility in vitro. The properties of the immobilized papain system were investigated by transmission electron microscopy, zeta potential, DLS, UV–vis absorption spectroscopy, FTIR spectroscopy, and X-ray diffraction. The prepared bionanomaterial exhibited a nanotriangular structure with a size of 150 nm and maintained the proteolytic activity of papain. In vitro analyses demonstrated that the immobilized papain system decreased the activation of phagocytic cells but did not induce toxicity. Based on the results obtained, we suggest that the novel bionanomaterial has great potential in biomedical applications in diseases such as psoriasis and wound

MEMBROS DA BANCA:
Presidente - 1508806 - WELTER CANTANHEDE DA SILVA
Interno - 1714193 - JOSE MILTON ELIAS DE MATOS
Interno - 1357378 - CARLA VERONICA RODARTE DE MOURA
Interno - 2157495 - ANDERSON NOGUEIRA MENDES
Externo ao Programa - 2199134 - MARCILIA PINHEIRO DA COSTA